This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents.
Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use.
Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.
Thirumurthy Velpandian is a Professor, heading the Ocular Pharmacology & Pharmacy Division at Dr. R.P. Centre for Ophthalmic Sciences at All India Institute of Medical Sciences, New Delhi. He has been involved in research, teaching and pharmaceutical patient care activities of ophthalmology. His area of interest is ocular pharmacokinetics of drugs, with reference to xenobiotic transporters across blood-ocular barriers, and developing animal models for various ophthalmic conditions. Pre-clinical drug development and delivery approaches are ongoing research collaborations. His laboratory is also involved in tear lipidomics, ocular QSPR, pharmacogenomics, as well as chemical and environmental issues related to ocular toxicity. He has been a visiting Professor to Harvard-MIT and a recipient of the Dr. Vinod Kumar Bhargava Award (2014) for Clinical Pharmacology and Drug Discovery by the National Academy of Medical Sciences, India. He currently serves as an Editor (Pharmacology) of Indian J Physiology and Pharmacology.
1. Ocular Pharmacology & Therapeutics- Origin, Principle, Challenges and Practices.- 2. Opportunities for the Development of Newer Drugs for Ocular use.- 3. Drug Transport Across Blood Ocular Barriers and Pharmacokinetics.- 4. Pharmacogenomics of Drugs in Ocular Therapeutics.- 5. Biochemistry of Eye and its Metabolic Functions.- 6. Drugs Acting Through Autonomic System for Ocular use.- 7. Ocular Hypotensive and Neuro-Protectants in Glaucoma.- 8. Steroidal and Non-Steroidal Anti-Inflammatory Agents for Ocular us.- 9. Anti-Angiogenic Agents and Photodynamic Therapy.- 10. Mucoadhesive Polymers and Ocular Lubricants.- 11. Antimicrobial Agents for Ocular use- Bacterial, Fungal, Viral and Protozoal Infections.- 12. Chemotherapy for Ocular Cancers.- 13. Ocular Diagnostic Agents.- 14. Systemic Toxicity of Drugs Applied on Eye.- 15. Extemporaneously used Drug Formulations for Ocular Emergencies.- 16. Preservatives for Topical Ocular Drug Formulations.- 17. Miscellaneous Drugs & Agents for Ocular use.- 18. Herbal Drugs For Ophthalmic use.- 19. Drug Delivery Systems for Ocular use.