This title provides students, scientists and health care clinicians with state-of-the-art information on the role of physical activity in alleviating insulin resistance. This book discusses the emergence of an exercise-deficient phenotype and details the effects of exercise training on selected aspects of substrate metabolism. The role of exercise interventions and endurance and resistance training programmes, for the prevention and treatment of insulin resistance are also covered. It includes recent developments in molecular and cellular biology that have led to the identification of novel targets and pathways for the treatment of insulin resistance and Type 2 diabetes.
John Hawley is currently Director of the Exercise Metabolism Research Group and Professor of Exercise Metabolism in the School of Medical Sciences at RMIT University, Melbourne, Australia. He has published over 140 peer-reviewed scientific papers, written over 80 articles for technical journals and has authored numerous book chapters for sports medicine and exercise biochemistry texts. Juleen Zierath is professor of physiology and head of section of integrative physiology at the department of surgical science, Karolinska Institutet, Stockholm, Sweden. Zierath is also an adjunct professor of biochemistry at Boston University School of Medicine.
Chapter 1. The Increasing Burden of Type 2 Diabetes: Magnitude, Causes, and Implications of the Epidemic; Chapter 2. Waging War on Type 2 Diabetes: Primary Prevention Through Exercise Biology; Chapter 3. Fatty Acid Uptake and Insulin Resistance; Chapter 4. Lipid Metabolism and Insulin Signaling; Chapter 5. Metabolic Inflexibility and Insulin Resistance; Chapter 6. Nutrient Sensor Links Obesity With Diabetes Risk; Chapter 7. Inflammation-induced Insulin Resistance in Obesity: When immunity Impacts on Metabolic Control; Chapter 8. Transcription Factors Regulating Exercise Adaptation; Chapter 9. Exercise and Calorie Restriction Use Different Mechanisms to Improve Insulin Sensitivity; Chapter 10. Mitochondrial Oxidative Capacity and Insulin Resistance; Chapter 11. Effects of Acute Exercise and Exercise Training on Insulin Action in Skeletal Muscle; Chapter 12. Resistance Exercise Training and the Management of Diabetes; Chapter 13. AMPK: The Master Switch for Type 2 Diabetes?; Chapter 14. Protein Kinase C and Insulin Resistance; Chapter 15. Evidence for the Prescription of Exercise as a Therapy.