Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate

Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate

By: Committee on Toxicology (author), Board on Environmental Studies and Toxicology (author), National Academy of Sciences (author), National Research Council (author), Subcommittee on the Toxicity of Diisopropyl Methylphosphonate (author), Division on Earth and Life Studies (author), Commission on Life Sciences (author)Paperback

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Description

Diisopropyl Methylphosphonate (DIMP) is a groundwater contaminant at the U.S. Army's Rocky Mountain Arsenal in Colorado. DIMP is a by-product created from the manufacture and detoxification of the nerve agent GB which the arsenal produced from 1953 to 1957. For awhile the Army and the State of Colorado disagreed upon the appropriate drinking-water contaminant guideline for DIMP. A drinking-water guideline of 600 micrograms per liter was established by the U.S. Environmental Protection Agency (EPA) in 1989 but the State of Colorado promulgated a lower guideline of 8 micrograms per liter. The significant difference between the two suggested values arose from the fact that both sides used different studies to determine their values. Colorado used one-generation reproductive toxicity study in mink, whereas EPA used a subchronic toxicity study in dogs. To resolve the disagreement, a two-generation reproductive study in mink was conducted. The Army asked the National Research Council (NRC) to independently evaluate the 1997 study and re-evaluate the drinking-water guideline for DIMP. This task was assigned to the Committee on Toxicology, which established the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, a multidisciplinary group of experts. The subcommittee evaluated the two-generation reproductive study as well as other studies relevant to the task. Data on the use of mink as a predictive model in toxicology were also reviewed. Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate is the subcommittee's report which shows that neither party was corrected in their DIMP guidelines. The report includes the subcommittee's evaluation and recommendations concerning the topic.

About Author

Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council

Contents

1 Front Matter; 2 Executive Summary; 3 Introduction; 4 Evaluation; 5 References; 6 Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate

Product Details

  • ISBN13: 9780309072557
  • Format: Paperback
  • Number Of Pages: 48
  • ID: 9780309072557
  • ISBN10: 0309072557

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  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
  • Store Delivery: Yes

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