This volume brings together the Perspectives and Topical Reviews published during 2000 in The Journal of Physiology, with the intention of making their content as accessible as possible to both students and researchers in physiology. The Journal of Physiology publishes original research papers that illustrate new physiological principles and mechanisms, with an emphasis on human and mammalian physiology. It is among the most rapidly published journals in its field, and has one of the highest citation indexes in physiology.
Topical reviews: signal transduction by G-Proteins, Rho-kinase and protein phophatase to smooth muscle and non-muscle myosin II A. P. Somlyo and A. V. Somlyo; Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say! H. T. Idriss, Y. A. Hannin, E. Boulpaep and S. Basavappa; Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium J. M. Nerbonne; Mammalian brainstem chemosensitive neurones: linking them to respiration in vitro D. Ballantyne and P. Scheid; Quantal currents at single-site central synapses C. Auger and A. Marty; The actin cytoskeleton in store-mediated calcium entry J. A. Rosado and S. O. Sage; Sympathetic vasodilation in human limbs M. J. Joyner and J. R. Halliwell; Molecular determinants of inactivation in voltage-gated Ca2+ channels S. Hering, S. Berjukow, S. Sokolov, R Marksteiner, R. G. Weiss, R. Kraus and E. N. Timin; Human ageing and the sympathoadrenal system D. R. Seals and M. D. Esler; Perspectives: when having the nerve is helped by having the muscle M. J. Rennie; The role of static and dynamic fusimotor activity during locomotion P. R. Murphy; Combining physiology and genetics in the zebrafish retina H. Baier and D. Copenhagen; Multiple forms of feedback inhibition by str. oriens inhibitory interneurons? C. J. McBain; Steroidal influences on oxytocin neurones G. Leng; What determines the initiation of the heartbeat? D. Terrar and L. Rigg; A slow NMDA channel: in search of a role S. Vicini and G. Rumbaugh; K+ channels and their distribution in large cortical pyramidal neurones J. F. Storm; Oxygen-sensing and K+-Cl- cotransport P. B. Dunham; Sleep of paradoxes J. Orem and W. Dunin-Barkowski; The synovial lining: a paradigm for connective tissue research? P. Winlove; Divergence in the behaviour of the dihydropiridine receptor in muscle H. Ch. Luettgau; The afferent signalling of fever C. M. Blatteis; Chronicle of skinned muscle fibres G. J. M. Steinen; Primary afferent depolarization produced in Ad and C fibres by glutamate spillover? New ways to look at old things P. Rudomin; NO and the regulation of VSOACs D. Duan and J. R. Hume; How to avoid running on empty M. J. Rennie; Keeping up with bicarbonate I. Novak; The Yin and Yang of the KATP channel F. M. Ashcroft; Towards an understanding of the function of the intrinsic cardiac ganglia D. C. Randall; Interleukins and exercise M. Gleeson; A window into the role of inhibitory and excitatory mechanisms of perception? L. G. Cohen; Calponin - knocked out but not down? M. P. Walsh.