Selected Topics in Mass Spectrometry in the Biomolecular Sciences: Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Biomol

Selected Topics in Mass Spectrometry in the Biomolecular Sciences: Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Biomol

By: etc. (editor), Richard Caprioli (editor)Hardback

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Description

Many fundamental aspects of the methods used in mass spectrometry are presented here, with reference to recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are included, together with optimised GC/MS interfacing systems and tools for quantitative analysis. There is also a comprehensive treatment of modern instrumentation for mass analysis and detection. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several contributions are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases. Fundamentals and applications are treated with the same degree of depth, and the first two parts of the book therefore provide a basis for the understanding of the biomolecular-applications section. The book is intended for advanced graduate students of chemistry who have learned some basic mass spectrometry, and is also suitable for PhD students in chemistry, biology and medicine, as well as researchers in academic and industrial laboratories.

Contents

Part 1 Methods in mass spectrometry: electrospray ionization - theory and application, S.J. Gaskell; atmospheric-pressure ionization (ESI and APCI), A. Raffaelli; matrix-assisted laser desorption-ionization (MALDI) mass spectrometry - principles and applications, M. Karas and U. Bahr; high-sensitivity ESI and MALDI MS, T.B. Farmer and R.M. Caprioli; optimized GS/MS interfacing systems and operating conditions, P.J. Arpino; quantitative analysis by mass spectrometry - some important considerations, M.W. Duncan; optimization of mass-spectrometric ionization-efficiency data, I.T. Ozgen et al; role of internal energy in mass-spectrometric fragmentation, K. Vekey; interaction of metal ions and protons with simple biomolecules; structure information from bond energies and entropy effects, B.A. Cerda et al; a promising marriage between theory and experiment - density-functional method versus mass spectrometry, T. Marino et al. Part 2 Instrumentation for mass analysis and detection: recent advances in magnet-sector mass spectrometry, O.V. Menirovskiy et al; quadrupole mass filters and quadrupole ion traps, R.G. Cooks et al; time-of-flight mass spectrometry, M.L. Vestal; combined analyzer technologies, P. Kofel and U.P. Schlunegger; Fourier-transform mass spectrometry; M.L. Easterling and I.J. Amster. Part 3 Application to biomolecules: protein characterization by MS in pharmaceutical industry, D. Muller et al; folding pathways of disulphide containing proteins, M. Ruoppolo et al; integration of chemical modification reactions and mass-spectrometric methods in protein characterization, S. Foti; PSD-MALDI analysis of peptides, B. Spengler; development of a mass-spectrometric approach for the characterization of haemoglobin adducts, P. Ferrante et al; reactivity of antineoplastic drugs with model peptides studied by advanced mass-spectrometry methodologies, V. Carbone et al; applications of mass spectrometry in biochemical studies of nucleosides, nucleotides and nucleic acids, R.P. Newton; MALDI mass analysis of oligonucleotides, U. Bahr and M. Karas; DNA adducts in human carcinogenesis, H. Bartsch; MALDI MS of oligo and polysaccharides, D. Garozzo; mass spectrometry of isoeicosanoids as novel lipid substances, R.C. Murphy and R.J. Waugh; the role of mass spectrometry in the characterization of plant metabolites from crude extracts, A. De Nino et al; environmental applications of mass spectrometry - toxaphene analysis, F.I. Onuska and R.J. Maguire; the determination of polar compounds in the aquatic environment, M.J.F. Suter; some mass-spectrometry contributions in the study of cultural heritage, P. Agozzino.

Product Details

  • ISBN13: 9780792348498
  • Format: Hardback
  • Number Of Pages: 612
  • ID: 9780792348498
  • ISBN10: 0792348494

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