A comprehensive, interdisciplinary review of the research on etiology and treatment of this chronic condition for which there is no known apparent cure. With an estimated prevalence rate of 13 per cent. SIB occurs most frequently among persons who are retarded and autistic. In this volume, the field's leading researchers examine a new generation of models and theories with a level of specificity far beyond what was heretofore imagined possible. From the burgeoning area of research on functional assessment and the behavioural and biological antecedents of SIB, to the role of Lesch-Nyhan Syndrome and opioid peptides, the work of these foremost basic, applied, and behavioural researchers is sure to greatly enhance feloow researchers', teachers', and clinicians' understanding of this devastating condition.
Self-injury - knowing what we're looking for; self-injury and comorbid behaviours in developmental, neurological, psychiatric and genetic disorders; epidemiology of self-injurious behaviour in mental retardation - a review; treatment - current standards of care and their research implications; environmental determinants of self-injurious behaviour; functional assessment and self-restraint; the impact of functional assessment on the treatment of self-injurious behaviour; evolution of stereotypy into self-injury; incidence of self-injurious behaviour - birth to three years; self-injurious behaviour in captive macaque monkeys; dopaminergic mechanisms in self-injurious behaviour and related disorders; pemoline and other dopaminergic models of self-biting behaviour; opioids and the maintenance of self-injurious behaviour; sleep and cyclical variables related to self-injurious and other destructive behaviours; self-injury and pain - models and mechanisms; temporal and force dynamics of self-injury; lessons from Lesch-Nyhan syndrome; neuroimaging studies in Lesch-Nyhan syndrome and Lesch-Nyhan variants; age-dependent reduction of brain dopamine - relationship of neonatal reduction of dopamine to self-injurious behaviour in Lesch-Nyhan syndrome and mental retardation; a new animal model for Lesch-Nyhan syndrome - calcium channel activation with bay K 8644; replacement therapy for the treatment of Lesch-Nyhan syndrome.