In 2004 the National research foundation (NRF) initiated a foresight exercise on the challenges of knowledge-making in social sciences, law and the humanities (SSLH) in South Africa in the 21st century. The main contributions to this project are collected in this volume. It is designed to open horizons about the value of and prospects for SSLH research, while simultaneously promoting and stimulating scholarship in this domain. The contributions provide a useful starting point for thinking about the current state of SSLH research, and gives researchers locked into single disciplinary perspectives a taste of the debates and trends in allied disciplines. They also provide an organising frame for a new, broad-based, and open conversation among the many interested parties involved in producing, reproducing and disseminating knowledge. It is hoped that this volume will contribute to a greater understanding of the demands of knowledge-making in the 21st century, and ultimately, to a realignment of the system of knowledge, research and innovation.