This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Supplies in one place all the information on this active and complex research topic and may stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. Fills the need of surgeons to understand the molecular mechanisms in hepatology. Provides a quick and comprehensive overview.
Prof. J.-F. Dufour, hepatologist at the University of Bern, is internationally recognized for bridging basic science and clincial practice. Prof. P.-A. Clavien, head of visceral surgery University Hospital Zurich, is a world renown investigator in the field of liver ischemia/reperfusion injury. Prof. Clavien successfully lead multi-authored texts having already published 3 books as editor: Malignant Liver Tumors, Blackwell Science Inc., May 1999 Medical Care of the Liver Transplant Patient (Killenberg/Clavien), Blackwell Science Inc. Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment (Clavien/Baillie),Blackwell Science Inc.
Part I Cell Types and Matrix: Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Part II Specific Signaling Pathways: IL-6/gp130/Stat3 - Vascular Endothelial Growth Factor Signaling.-. Insulin Pathway.- Nature and Function of Hepatic Tumor Necrosis Factor-a Signaling.- The Fas/FasL Signaling Pathway.- TGF-ss and the Smad Pathway in Liver Fibrogenesis.- Interferon Signaling.- CD14 and Toll Receptor.- The Wnt/ss-Catenin Pathway.- Notch Signaling in Liver Disease.- Extracellular ATP: Emerging Roles of Purinergic Signaling.- Calcium Signaling.- MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival.- PI3K,PTEN and Akt.- TOR Signaling and Cell Growth Control.- Peroxisome Proliferator Activated Receptors.- Transcriptional Response to cAMP in the Liver.- Heme Oxygenase System.- Nitric Oxide.- Hypoxia-Inducible Factor-1 Signaling System.- Cyclins and CDKs in Liver Diseases.- Telomeres amd Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis.- NF-kB.- Ceramide: Cell Regulation from a Lipid Perspective.- Apoptosis and Mitochondria.- Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Diseases.- Biological Clock in the Liver.- Part III Horizons: Pharmacogenomics of Cholestatic Liver Disease.- Proteomics of Signal Transduction Pathways.- Subject Index.