This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Jose A. Pomposo is IKERBASQUE Research Professor at the Materials Physics Department of the University of the Basque Country - UPV/EHU. He is in charge of the Chemistry Laboratory oriented to Polymer Synthesis of the Polymers & Soft Matter Group. He received his Ph.D. from the University of the Basque Country in 1994. He spent 12 years as Head of the New Materials Department in a Technological Research Center, and 1 year at the Donostia International Physics Center - DIPC. He has contributed to more than 130 scientific publications and 9 international patents. His research interests include the synthesis of uniform soft nano-objects, research on the structure, dynamics & self-assembly behaviour of complex single-chain nano-objects, and the construction of hybrid organic nanostructures.
SYNTHETIC METHODS OF SINGLE-CHAIN POLYMER NANOPARTICLES Introduction Single-Chain Rings Covalent Single-Chain Polymer Nanoparticles Supramolecular Single-Chain Polymer Nanoparticles Dynamic Covalent Single-Chain Polymer Nanoparticles Conclusions and Future Outlook MOLECULAR DYNAMICS SIMULATIONS OF SINGLE-CHAIN POLYMER NANOPARTICLES Introduction Sparse Single-Chain Polymer Nanoparticles Globular Single-Chain Polymer Nanoparticles Concentrated Solutions of Single-Chain Polymer Nanoparticles Conclusions and Future Outlook CHARACTERIZATION OF SINGLE-CHAIN POLYMER NANOPARTICLES: ANALYTICAL TECHNIQUES Introduction Molar Mass Characterization Size Characterization Structural Characterization Thermal Characterization Rheological Characterization Other Techniques CHARACTERIZATION OF SINGLE-CHAIN POLYMER NANOPARTICLES: SCATTERING TECHNIQUES Introduction Small-Angle Neutron Scattering Characterization Small-Angle X-ray Scattering Characterization Static Light Scattering Characterization Dynamic Light Scattering Characterization Final Remarks DYNAMICALLY FOLDED SINGLE-CHAIN POLYMER NANOPARTICLES Introduction Single-Chain Polymer Nanoparticles vs Conventional Nanoparticles Preparation of Dynamically Folded Single-Chain Polymer Nanoparticles Characterization of Dynamically Folded Single-Chain Polymer Nanoparticles Conclusions and Outlook METALLO-CONTAINING SINGLE-CHAIN POLYMER NANOPARTICLES Introduction Single-Chain Polymer Nanoparticles vs Dendrimers Synthesis of Metallo-Containing Single-Chain Polymer Nanoparticles Characterization of Metallo-Containing Single-Chain Polymer Nanoparticles Conclusions and Future Directions COLLOIDAL UNIMOLECULAR NANOPARTICLES Introduction Synthesis of Colloidal Unimolecular Nanoparticles Characterization of Colloidal Unimolecular Nanoparticles Physico-Chemical and Rheological Properties of Colloidal Unimolecular Nanoparticles Conclusions and Future Outlook SINGLE-CHAIN NANOPARTICLES VIA SELF-FOLDING AMPHIPHILIC COPOLYMERS IN WATER Introduction Synthesis of Single-Chain Nanoparticles via Self-Folding Amphiphilic Copolymers in Water Characterization of Single-Chain Nanoparticles via Self-Folding Amphiphilic Copolymers in Water Conclusions and Future Directions APPLICATIONS OF SINGLE-CHAIN POLYMER NANOPARTICLES Introduction Protein Mimicry Nanomedicine Applications Catalysis Applications Other Uses Future Outlook