Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types. This book explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration. The authors present the most current research on sodium channels and neuronal function.* Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy. * Includes coverage of channelopathies, sodium channel gene expression, the modulation of sodium channels, and molecular mechanisms of gating and drug block of sodium channels.
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Chair's Introduction: Sodium Channels and Neuronal Dysfunction - Emerging Concepts, Converging Themes (Stephen G. Waxman). Studies of Multimodal Gating of the Sodium Channel (Richard D. Keynes). Molecular Basis for Function in Sodium Channels (Richard Horn). Diverse Functions and Dynamic Expression of Neuronal Sodium Channels (Stephen G. Waxman, et al.). Enhanced Transmission of Glutamate Current Flowing from the Dendrite to the Soma in Rat Neocortical Layer 5 Neurons (Wayne E. Crill, et al.). Mutations of Voltage-gated Sodium Channels in Movement Disorders End Epilepsy (Miriam H. Meisler, et al.). Channelopathies: Episodic Disorders of the Nervous System (Louis Ptacek). Sodium Channels Gene Expression and Epilepsy (Jeffrey L. Noebels). Subunits: Players in Neuronal Hyperexcitability? (Lori L. Isom). Modulation of Sodium Channels in Primary Afferent Neurons (Stuart Bevan, et al.). Sodium Channels in Primary Sensory Neurons: Relationship to Pain States (John N. Wood, et al.). Sodium Channels an Epilepy Electrophysiology (Michael M. Segal). Therapuetic Concentrations of Local Anaesthetics Unveil the Potential Role of Sodium Channels in Neuropathic Pain (Gary R. Strichartz, et al.). Molecular Mechanisms of Gating and Drug Block of Sodium Channels (William A. Catterall). Final General Discussion. Index of Contributors. Subject Index.