Soft tissue tumors (STTs) are frequently misdiagnosed in inexperienced hands. Having diagnosed and treated hundreds of patients with these difficult tumors in the last few years, Institut Curie physicians have collected core data contributing to breakthrough research into the morphological, biological, and molecular aspects of soft tissue tumors, resulting in valuable translational and clinical applications to patient treatment. Soft Tissue Tumors: A Multidisciplinary, Decisional Diagnostic Approach presents a distillation of these experiences, combined with valuable data and perspectives contributed by senior pathologists, oncologists, and radiologists from several of the world s other leading cancer centers of excellence.
Jerzy Klijanienko, MD is Senior Surgical Pathologist and a Clinical Oncologist, as well as Head of Cytopathology, at the Institut Curie in Paris, France. He previously published a large, well-received series of articles concerning cytopathology in soft tissue tumors and has written a best-selling monograph on the pathology and diagnosis of salivary tumors. R al Lagac , MD, is Clinical Pathologist at the H pital Universitaire in Queb c, Canada, where he specializes in the study, diagnosis, and treatment of soft tissue tumors. He has a particular interest in the morphology and molecular biology of tumors, and has widely published in these areas.
Foreword (Alain Verhest). Preface. Acknowledgments. Contributors. 1 Clinical approach in soft tissue tumors (Francois Goldwasser). 1.1 Epidemiology. 1.2 Clinics and clinical profiles. 1.3 Clinical differential diagnosis. 1.4 The importance of molecular diagnosis and its perspectives. 1.5 Treatment strategies. 2 Radiological diagnostic approach in soft tissue tumors (Herve Brisse). 2.1 Introduction. 2.2 Patient management. 2.3 Imaging techniques. 2.4 Radiologic characterization. 2.5 Tumor biopsy. 3 Sampling procedure, fine needle aspiration (FNA), and core needle biopsy (CNB) (Henryk A. Doma ski). 3.1 Advantages and limitations of FNA and CNB in soft tissue lesions. 3.2 Techniques of FNA and CNB as applied to soft tissue lesions. 3.3 Processing the FNA and CNB samples and preparation of the FNA specimen for ancillary techniques. 3.4 Challenges in the FNA and CNB of soft tissue. 3.5 Complications of FNA and CNB of soft tissue. 4 Ancillary techniques. 4.1 Immunocytochemistry (Carlos Bedrossian). 4.2 Immunohistochemistry (Real Lagace). 4.3 Genetic Techniques (Jerome Couturier). 4.4 Grading of soft tissue tumors (Real Lagace). 4.5 Future investigations of ancillary techniques (Stamatios Theocharis). 5 Principal aspects in fine needle aspiration and core needle biopsies (Jerzy Klijanienko and Real Lagace). 5.1 Normal tissue. 5.2 Cytologic classification of soft tissue tumors based on the principal patterns. 5.3 Diagnostic accuracy of FNA in soft tissue tumors. 5.4 Smear composition and the differential diagnosis of soft tissue tumors. 6 Particular aspects (Jerzy Klijanienko and Real Lagace). 6.1 Low-grade spindle cell tumors. 6.1.1 Fibromatoses and Desmoids. 6.1.2 Nodular Fasciitis. 6.1.3 Dermatofibrosarcoma Protuberans. 6.1.4 Benign Fibrous Histiocytoma (Cellular and Atypical Variants). 6.1.5 Solitary Fibrous Tumor. 6.2 Tumors with fibrillary stroma. 6.2.1 Benign Peripheral Nerve Sheath Tumors (Schwannoma, Ancient Schwannoma and Neurofibroma). 6.2.2 Low-Grade Malignant Peripheral Nerve Sheath Tumor. 6.3 Malignant spindle cell tumors. 6.3.1 Leiomyosarcoma. 6.3.2 Synovial Sarcoma. 6.3.3 Fibrosarcoma. 6.3.4 Malignant Fibrous Histiocytoma Storiform Pattern. 6.3.5 Malignant Peripheral Nerve Sheath Tumor. 6.3.6 Spindle Cell Angiosarcoma. 6.3.7 Kaposi Sarcoma. 6.4 Myxoid tumors. 6.4.1 Myxoid Liposarcoma (With or Without Round or Spindle Cells). 6.4.2 Myxofibrosarcoma. 6.4.3 Myxoid Leiomyosarcoma. 6.4.4 Myxoma and Cellular Myxoma. 6.4.5 Chordoma. 6.4.6 Extraskeletal Myxoid Chondrosarcoma. 6.5 Atypical lipomatous tumors. 6.5.1 Well-Differentiated liposarcoma / Atypical Lipoma. 6.5.2 Spindle Cell and Pleomorphic Lipoma. 6.6 Epithelioid tumors. 6.6.1 Epithelioid Sarcoma. 6.6.2 Gastrointestinal Stromal Tumor (GIST)/Epithelioid Leiomyosarcoma. 6.6.3 Epithelioid Angiosarcoma. 6.6.4 Granular Cell Tumor. 6.6.5 Rhabdoid Tumor. 6.6.6 Alveolar Soft Part Sarcoma. 6.6.7 Clear Cell Sarcoma. 6.6.8 Malignant Melanoma and Metastases. 6.7 Pleomorphic sarcomas. 6.7.1 Pleomorphic Malignant Fibrous Histiocytoma. 6.7.2 Pleomorphic Liposarcoma. 6.7.3 Pleomorphic Leiomyosarcoma and Rhabdomyosarcoma. 6.7.4 Extraskeletal Osteosarcoma. 6.7.5 Pleomorphic Malignant Peripheral Nerve Sheath Tumor. 6.8 Round cell sarcomas. 6.8.1 Embryonnal and Alveolar Rhabdomyosarcoma. 6.8.2 Ewing Sarcoma/Peripheral Neuroectodermal Tumor. 6.8.3 Desmoplastic Small Round Cell Tumor. 6.8.4 Extraskeletal Mesenchymal Chondrosarcoma. 6.8.5 Poorly Differentiated Synovial Sarcoma. Index.