Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge.
Foreword/Dr. Atsushi Miyajima, Tokyo University, Japan Preface/Dr. Nobuhiro Ohkohchi, University of Tsukuba, Japan Introduction/Dr. Yun-Wen Zheng, University of Tsukuba, Japan Molecular mechanisms of liver development: lessons from knockout mice and mutant fish The regulation of proliferation and maturation of hepatic progenitor cells during liver development Plasticity of liver epithelial cells in healthy and injured livers Stem cells in the liver and the organ size control Generation of liver progenitor cells by chemical reprogramming Generation of hepatocytes by transdifferentiation Generation of liver organoids and the potential application Reconstitution of liver tissue with engineered multicellular spheroids Role of platelet, blood stem cell and thrombopoietin in liver regeneration and liver diseases Dynamic tissue remodeling in chronic liver diseases: abnormal proliferation and differentiation of hepatocytes and bile ducts/ductules Stem cells in the hepato-biliary system and in the development of cancer: the points of view from a surgeon Stem cells in the chronically injured livers and the interaction with their environment Stem cells in the liver cancers and the controversial Characteristics and clinical significance of liver cancer stem cells Clinical application of stem cells in liver diseases: from bench to bedside