Stem cell biology has gained tremendous interest in recent years, driven by the hope of finding cures for several diseases through transplantation medicine. Various types of stem cells have been identified from preimplantation embryos, the fetus, placenta and adult. The isolation of human embryonic stem cells has been considered the biggest breakthrough of the 21st century. Some of these stem cell types are charged with ethical controversies although they are versatile and offer tremendous potential for finding cures for incurable diseases. In fact, cures for diabetes, heart diseases, Parkinson's, Alzheimer's, and many other diseases via stem cell research is expected within the next 10 years. The documentation of the latest information on these various stem cell types is compartmentalized in different journals and texts. This book brings together the state-of-the-art on all the types of stem cells written by giants in the respective fields. It is hoped that knowledge of one stem cell type will complement the other and much can be learned by interaction.
This book is aimed at undergraduates, postgraduates, scientists, embryologists, tissue engineers, doctors and biomedical scientists with an interest in stem cell research. It is different from other texts in that it is very comprehensive, covering all aspects of stem cells. Additionally, all the various chapters are written by renowned scientists in the specific fields. The topics are uniquely treated in that they cover research at the laboratory bench as well as the clinical applications. Many of the chapters carry extensive self-explanatory figures, colored photographs, graphics and tables. Both the editors are also renowned in the stem cell field, and both come from medical disciplines and are senior university academics with excellent track records.
A Bongso & E H Lee: Stem Cells: Their Definition, Classification and Sources; A Bongso: From Human Embryos to Embryonic Stem Cells -- Their Derivation, Propogation and Properties; I Weissman & D Kraft: Human Hemopoietic Stem Cells; P Andrews: Characterization of Human Stem Cells; N Benvenisty & B Bulum: Undifferentiation and Differentiation in Vitro and in Vivo of Human Embryonic Stem Cells; M Pera: Multipotency, Pluripotency and Totipotency of Stem Cells; Y Itskovitz-Eldor: Subcloning, Spontaneous and Controlled Differentiation of Stem Cells; S Y Moon et al.: Therapeutic Cloning -- Derivation and Propagation of Stem Cells in the Human by Somatic Cell Nuclear Transfer; M Rao: Transcriptome Profiling of Stem Cells; J Burley & J Harris: Legal and Ethical Issues Surrounding Stem Cell Biology; C Mummery: Differentiation of Human Embryonic Stem Cells to Cardiomyocytes; D Tan: Stem Cells in the Eye; J Shapiro & S Nanji: Progress in Immunological Tolerance and Islet Cell Transplantation; B Soria: Differentiation of Human Adult Stem Cells to Islet Cells of the Pancreas; P Tan: Bone Marrow Stem Cells for the Treatment of Leukemia and Other Blood Disorders; D Hutmacher: Bone Repair with Adult Stem Cells; E H Lee & J B Richardson: Stem Cells and Cartilage; J Goh: Ligament and Tendon Repair with Adult Stem Cells; A Brivanlou: Feeder-Free Derivation and Propagation of Human Embryonic Stem Cells; M Alison: Liver Stem Cells; F Faendrich: Stem Cell Transplantation in Animal Models and Their Outcome; R Calne: Challenges of Cell Based Therapies; G Daley: Human Embryonic Stem Cells and Germ Cell Development; M Carpenter: Gene Imprinting and X-Inactivation in Human Embryonic Stem Cells; M Bhatia: Differentiation of Human Embryonic Stem Cells into Blood Cells; S C Zhang: Differentiating Stem Cells into Neurons; G Schatten & C Navana: Hurdles to Overcome in Improving the Efficiency of Therapeutic Cloning.