This book provides up-to-date information on some of the most important aspects of ryanodine receptor function and has been written by experts in the field. Included are reviews of the latest experimental data, critical assessments of the mechanisms of ryanodine receptor activation and regulation, and the role of the channel in controlling intracellular Ca2+ release.The approach to this subject is new. The book focuses on the biochemical and biophysical aspects of ryanodine receptor research, with particular emphasis on the single channel properties of reconstituted ryanodine receptors.
An overview of ryanodine receptor structure and function, R. Sitsapen and A.J. Williams; characteristics of ryanodine receptor type 3 isoform (RyR3) and its homologues, Y. Ogawa and T. Murayama; the skeletal muscle calcium-release channel visualised by electron cryomicroscopy, E.V. Orlova et al; regulation of ryanodine receptor channel gating, R. Sitsapen; ryanodine receptor ion conduction and selectivity, A.J. Williams; ryanodine binding sites on the sarcoplasmic reticulum Ca2+ release channel, I.I. Serysheva and S.L. Hamilton; the ryanodine receptor - a report from the ryanoids, W. Welch; phosphorylation of ryanodine receptors, J.A. Airey and R. He; Ca2+ release channel/ryanodine receptor -L-type Ca2+; channel/dihydropyridine receptor interactions in skeletal muscle, G. Meissner; regulation of ryanodine receptor by peptide toxins, G.B. Gurrola and H.H. Valdivia; chemical modification of ryanodine receptor/Ca2+ release channel activity, V. Shoshan-Barmatz and W. Feng; the role of the ryanodine receptor in inherited muscle diseases, C.F. Louis and J.R. Mickelson; ryanodine receptor adaptation, P. Velez et al; adaptation, inactivation and inhibition in ryanodine receptors, G.D. Lamb and D.R. Laver; regulation of SR calcium release in intact ventricular myocytes, D.M. Bers.