Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products (Volume 59)

Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products (Volume 59)

By: William H. Pearson (editor), Albert Padwa (editor)Paperback

Up to 2 WeeksUsually despatched within 2 weeks

Description

Dipolar cycloaddition chemistry has found many useful synthetic applications, particularly with respect to the preparation of compounds with new chiral centers. This approach toward asymmetric syntheses is of major importance in both the pharmaceutical and agricultural industries. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products provides a comprehensive, current reference for the synthesis of complex molecules based on cycloaddition reactions. Updating Albert Padwa's popular 1984 volume, this new edition shifts the text's focus from theory, structure, reactivities, and selectivities to synthetic applications. Both carbonyl ylides and nitronates, important members of the 1,3-dipole family that were not reviewed previously, are now included. Beyond the ability of the 1,3-dipolar cycloaddition reaction to produce heterocycles, its importance extends to two other areas of organic synthesis, both of which are included in the current volume. First, the heteroatom-containing cycloadducts may be transformed into a variety of other functionalized organic molecules, whether cyclic or acyclic. Second, many 1,3-dipolar cycloadditions have the ability to generate rings (and the functionality derived from transformations of such rings) containing several contiguous stereocenters in one synthetic operation. The authors deal with relative stereocontrol in 1,3-dipolar cycloadditions in detail. Asymmetric versions of these dipolar cycloadditions represent an entirely new aspect of this new edition.

About Author

ALBERT PADWA, PhD, is the William P. Timmie Professor of Chemistry at Emory University in Atlanta, Georgia. WILLIAM H. PEARSON, PhD, is Professor of Chemistry at the University of Michigan in Ann Arbor, Michigan.

Contents

Nitrones (Jason N. Martin and Raymond C. F. Jones). Nitronates (Scott E. Denmark and Jeromy J. Cottell). Azomethine Ylides (L. M. Harwood and R. J. Vickers). Carbonyl Ylides (Mark C. McMills and Dennis Wright). Thiocarbonyl Ylides (Grzegorz Mloston and Heinz Heimgartner). Nitrile Oxides (Volker Jager and Pedro A. Colinas). Nitrile Ylides and Nitrile Imines (John T. Sharp). Diazoalkanes (Gerhard Maas). Azides (Chin-Kang Sha and A. K. Mohanakrishnan). Mesoionic Ring Systems (Gordon W. Gribble). Effect of External Reagents (Shuji Kanemasa). Asymmetric Reactions (Kurt Vesterager Gothelf and Karl Anker Jorgensen). Index.

Product Details

  • ISBN13: 9780471280613
  • Format: Paperback
  • Number Of Pages: 952
  • ID: 9780471280613
  • weight: 1272
  • ISBN10: 0471280615
  • edition: Volume 59

Delivery Information

  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
  • Store Delivery: Yes

Prices are for internet purchases only. Prices and availability in WHSmith Stores may vary significantly

Close