Targeted Therapy in Translational Cancer Research (Translational Oncology)

Targeted Therapy in Translational Cancer Research (Translational Oncology)

By: Razelle Kurzrock (editor), Apostolia-Maria Tsimberidou (editor), Kenneth C. Anderson (editor), Ernest T. Hawk (series_editor), Robert C. Bast (series_editor), Maurie Markman (series_editor)Hardback

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Description

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. * Introduces cutting-edge bench to bedside and back breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer * Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine * Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

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About Author

Apostolia-Maria Tsimberidou, MD PhD Department of Investigational Cancer Therapeutics The University of Texas MD Anderson Cancer Center Houston, TX, USA Razelle Kurzrock Center for Personalized Cancer Therapy, UC San Diego - Moores Cancer Center La Jolla, CA, USA Kenneth C. Anderson MD LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA

Contents

List of Contributors, vii Series Foreword, xiii Foreword, xv Preface, xvii Part I Principles of Targeted Therapies 1 Toward Personalized Therapy for Cancer, 3 Ashley M. Holder and FundaMeric-Bernstam 2 Combining Targeted Therapies, 14 Jordi Rodon, Analia Azaro, Davis Torrejon, and Razelle Kurzrock 3 Principles of Targeted Immunotherapy, 27 Susanne H. C. Baumeister and Glenn Dranoff 4 Cancer Stem Cell Principles, 39 Allison C. Sharrow, Gabriel Ghiaur, and Richard J. Jones 5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47 Hua Fang and Yves A. DeClerck 6 The Role of Angiogenesis in Cancer, 64 Morgan Taylor, Robert L. Coleman, and Anil K. Sood 7 Epigenetics and Epigenetic Therapy of Cancer, 72 Omotayo Fasan, Patrick Boland, PatriciaKropf, and Jean-Pierre J. Issa 8 The Role of microRNAs in Cancer, 80 Gianpiero Di Leva and Carlo M. Croce 9 AcuteMyeloidLeukemia, 89 Ofir Wolach and Richard M. Stone 10 Targeted and Functional Imaging, 101 Jian Q. (Michael) Yu, Drew A. Torigian, and Abass Alavi Part II Targeted Therapy in Hematological Malignancies 11 Targeted Therapies in Chronic Myeloid Leukemia, 113 Elias Jabbour and Jorge Cortes 12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121 Nitin Jain, Susan O Brien, and Farhad Ravandi-Kashani 13 Chronic Lymphocytic Leukemia, 130 Preetesh Jain and Susan O Brien 14 Multiple Myeloma, 145 Giada Bianchi and Kenneth C. Anderson 15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157 Jens G. Lohr and Birgit Knoechel 16 Targeted Therapy in Myelodysplastic Syndromes, 162 Guillermo Montalb'an-Bravo and Guillermo Garc'ya-Manero 17 Lymphoma and Targeted Therapies, 169 Sonali M. Smith and Julie M. Vose Part III Targeted Therapy in Solid Tumors 18 Targeted Therapy in Solid Tumors: Brain, 179 Shiao-PeiWeathers, Barbara J. O Brien, John F. de Groot, andW. K. Alfred Yung 19 Targeted Therapy for Breast Cancer, 190 Harold J. Burstein 20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193 Maen Abdelrahim, Scott Kopetz, and David Menter 21 Endometrial Cancer, 205 Jessica L. Bowser, Russell R. Broaddus, Robert L. Coleman, and Shannon N. Westin 22 Targeted Therapy in Solid Tumors: Head and Neck, 216 Marcus M. Monroe and Jeffrey N. Myers 23 Targeted Therapy in Solid Tumors: Lung Cancer, 224 Saiama N.Waqar, Daniel Morgensztern, and Roy S. Herbst 24 Targeted Therapy in Melanoma, 231 Keith T. Flaherty 25 Ovarian Cancer, 240 Shannon N.Westin, Larissa A. Meyer, and Robert L. Coleman 26 Molecular Therapeutics: Pancreatic Cancer, 255 David Fogelman, Milind Javle, and James Abbruzzese 27 Targeted Therapies for Pediatric Solid Tumors, 263 Jasmine Quynh Dao and Patrick A. Zweidler-McKay 28 Prostate Cancer, 273 William G. Nelson, Michael C. Haffner, and Srinivasan Yegnasubramanian 29 Renal Cell Carcinoma and Targeted Therapy, 287 Benjamin A. Gartrell, Alexander C. Small, William K. Oh, and Matthew D. Galsky 30 Targeted Therapy in Solid Tumors: Sarcomas, 296 Anthony P. Conley, Vinod Ravi, and Shreyaskumar Patel Part IV Targeted Therapy for Specific Molecular Aberrations 31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305 Javier Munoz and Filip Janku 32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315 Samuel J. Klempner,Thanh-Trang Vo, Andrea P. Myers, and Lewis C. Cantley 33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325 Saeed Rafii, Stan Kaye and Susana Banerjee 34 Targeting the c-Met Kinase, 341 Chad Tang, M. Angelica Cortez, David Hong, and James W. Welsh 35 KIT Kinase, 347 Scott E. Woodman 36 TP53, 353 Kensuke Kojima and Michael Andreeff Part V Future Perspectives 37 Future Perspectives, 363 Rabih Said and Apostolia-Maria Tsimberidou Index, 371

Product Details

  • publication date: 11/12/2015
  • ISBN13: 9781118468579
  • Format: Hardback
  • Number Of Pages: 400
  • ID: 9781118468579
  • weight: 1410
  • ISBN10: 1118468570

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  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
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