This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A and the effects of fluorosis, dioxin and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp and information on new strategies that induce pulp mineralization.
Michel Goldberg is Professor Emeritus de categorie exceptionnelle at the University of Paris V (University Rene Descartes). He has served on many committees for INSERM and for the International Association for Dental Research (IADR). Dr. Goldberg is a Past President of the IADR Mineralized Tissue Group and the Pulp Biology Group. He has been a member of the IADR Continental European Division since 1973 and has served on their board in numerous capacities, through to President and Past President. During his career, Dr. Goldberg has sat on scientific advisory boards for many international dental conferences. He was the Scientific President for the Annual Congress of the Association Dentaire Francaise (ADF) in 1992 and 2000 and presided over the annual ADF congress in 2003. He is a widely published author and co-author, with more than 200 scientific articles to his name as well as 11 books. He is a member of the editorial board of the Journal of Dental Research and a member of the board of advisory editors for numerous publications. Dr. Goldberg is a recipient of the Chevalier Ordre National du Merite; he was also awarded the Distinguished Service Award from the IADR in 2003 and the IADR's Distinguished Scientist Award for Pulp Biology Research in 2006.
PULP BIOLOGY: Pulp Development.- Pulp Anatomy and Characterization of Pulp Cells.- Pulp Extracellular Matrix.- Pulp Vascularization.- Pulp Innervation.- Inflammatory Process in the Dental Pulp.- Pulp Aging: Fibrosis and Calcospherites. PULP PATHOLOGY: Pulp Inflammation: From the Reversible Pulpitis to Pulp Necrosis.- Reactionary and Reparative Dentin.- Genetic Alterations: Dentinogenesis Imperfecta, Dentin Dysplasia.- Pulp Reaction to Dental Materials.- Effects of Bisphenol A on the Dental Pulp.- Effects on Pulp of Fluorosis, Dioxide and Other Toxic Agents. PULP REPAIR AND REGENERATION: Experimental in vivo Approaches of Pulp Regeneration.- Pulp Stem Cells - Niches of Stem Cells.- Regeneration of a Living Pulp.- Scaffolds for pulp repair and regeneration.- Endodontic Substitute: Induced Pulp Mineralization.