Sarcoplasmic reticulum is a form of endoplasmic reticulum found in large quantities in mature muscle cells. Anthony Martonosi presents general information about the development and function of the sarcoplasmic reticulum within a framework of contemporary research on the molecular biology of biosynthetic and signaling processes. Focusing on the development of the sarcoplasmic reticulum, Martonosi demonstrates the regulatory functions that control the production of its molecular components and investigates the interaction of these lipid and protein molecules with the myogenic, neurogenic and hormonal stimuli present in developing muscle cells. Martonosi provides extensive experimental support throughout the book.
1. Introduction to Muscle Development 2. Transcriptional Regulation of Gene Expression 3. The Development of Sarcoplasmic Reticulum in Skeletal Muscle (SR) and the Expression of Ca-AT Pase 4. The Synthesis and Insertion of Lumenal Sarcoplasmic Reticulum Proteins During Development of Skeletal Muscle 5. Regulation of Sarcoplasmic Reticulum Protein Composition and Turnover by Proteolysis 6. Regulation of the Phospholipid Composition of Sarcoplasmic Reticulum During Development 7. Development of Excitation-Contraction Coupling Apparatus 8. The Expression of Dihydropyridine Receptor Channel During Skeletal Muscle Development 9. The Ryanodine Receptor Ca Channel (RyR) 10. The Role of Ca in the Regulation of the Expression of Ca-AtPase in Muscle and Non-Muscle Cells 11. The Role of Ca in the Expression of the Endoplasmic Reticulum Chaperon Proteins GRP78(BiP) and GRP94 12. Transcriptional Regulation of c-fos Gene 13. Regulation of the Expression of Acetylcholine Receptor (AchR0, in Muscle by Electrical Activity and Ca 14. Effects of Calcium and Calcium Ionophores and Channel Blockers of the Synthesis of Other Muscle Proteins 15. The Regulation of the Expression of Na, K-ATPase by Na, K, and Ca 16. Regulation of Prolactin Synthesis by Calcium 17. Regulation of the Expression of Metallothionein 18. The Role of Calcium in Signal Transduction Between the Cytoplasm and Nuclei. Excitation-Transcription Coupling