The title The End of Science? asks not whether science itself is about to end or even to wane, but whether people will stop claiming that science knows nature as it is. Science, it suggests, may know nature only as the scientist sees it. Or the title suggests that, in knowing nature, scientists to some extent create nature. No one bothers to ask philosophers or theologians, poets, or politicians, workers or bosses whether they know the world as it is. It is common knowledge that the world for which they speak has been affected already by their description of that world. Will not the same fate strike scientists now? Has it not already? This is the basic issue that the six distinguished contributors address. They include Sandra Harding, Sheldon Lee Glashow, Ian Hacking, Mary Hesse, Gerald Holton, and Gunther S. Stent. Co-published with the Nobel Conference.