The Lymphoid Neoplasms 3ed (3rd New edition)

The Lymphoid Neoplasms 3ed (3rd New edition)

By: Ian T. Magrath (author)Hardback

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Description

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

About Author

Ian T. Magrath DSc (Med), FRCP, FRCPath President, International Network for Cancer Treatment and Research, Adjunct Professor of Pediatrics, Uniformed Services University of the Health Sciences, International Network for Cancer Treatment and Research, Brussels, Belgium Section editors: Kishor Bhatia PhD, FRCPath Director, AIDS Malignancy Program OHAM, NCI, NIH Bethesda, MD USA Paolo Boffetta MD, MPH Head of Environment Section, IARC Lifestyle and Cancer Group International Agency for Research on Cancer Lyon France Claire Dearden BSc, MD, FRCP, FRCPath Consultant Haematologist Department of Haemato-Oncology Royal Marsden NHS Foundation Trust and Institute of Cancer Research London UK Volker Diehl MD, PhD Professor of Internal Medicine, Hematology and Oncology Honorary Chairman of German Hodgkin Study Group (GHSG) Former Head of Department I of Internal Medicine University Hospital Cologne Cologne Germany Randy D. Gascoyne MD, FRCPC Clinical Professor of Pathology Department of Pathology and Laboratory Medicine British Columbia Cancer Agency and The University of British Columbia Research Director, Centre for Lymphoid Cancers Senior Scientist, BC Cancer Research Centre Vancouver, BC Canada Hans Konrad MA1/4ller-Hermelink Prof. Dr. Dr. h. c. Professor and Chairman Institute of Pathology University of WA1/4rzburg WA1/4rzburg Germany Michael Potter MD Scientist, Emeritus Laboratory of Cell Biology and Genetics National Cancer Institute, NIH Bethesda, MD USA Ama Z. S. Rohatiner MD, FRCP Professor of Haemato-Oncology Department of Medical Oncology, St. Bartholomew's Hospital London UK

Contents

INTRODUCTION Introduction to the lymphoid neoplasms Historical perspective: the evolution of modern concepts of lymphoid neoplasia EPIDEMIOLOGY Descriptive epidemiology Causes and prevention of lymphoma Immunologic and genetic predisposition Epidemiology of exogenous human retroviruses associated with hematologic malignancies Herpesviruses and lymphoma Other microorganisms associated with lymphoid neoplasms IMMUNOBIOLOGY Overview of the immune system Ontogeny of T and natural killer cells Ontogeny of B cells Cellular immunobiology of lymph nodes and spleen Cellular immunobiology of extranodal lymphoid tissue Biology of plasma cells Interleukins and lymphoid neoplasia Lymphocyte homing and the dissemination of lymphoid malignancies Mouse models of human B lymphoid neoplasms CLASSIFICATION AND PATHOGENESIS Classification of lymphoid neoplasms Borderlands between pathological entities: composite lymphomas Chromosomal and molecular alterations in lymphoid malignancies: basic principles and detection methods Molecular basis of chromosomal translocations Genesis and consequences of genetic lesions in lymphoma classification Gene expression patterns in lymphoma classification Immunodeficieny, inherited and acquired, and lymphomagenesis Chronic inflammation, including autoimmunity, and lymphogenesis PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS Lymphoblastic lymphomas and leukemias Chronic lymphoid leukemias and u heavy chain disease Hairy cell leukemia Mantle cell lymphoma Marginal zone lymphomas Follicular lymphoma Burkitt lymphoma Diffuse large B cell lymphomas Hodgkin lymphoma Plasma cell neoplasms Natural killer (NK) cell neoplasms Anaplastic large cell lymphoma Mycosis fungoides and Sezary Syndrome: pathophysiology and pathology Other peripheral T cell lymphomas: pathology and molecular pathogenesis PRESENTING FEATURES, DIAGNOSIS AND STAGING Presenting features of lymphoid neoplasms The art of histological diagnosis Immunophenotyping as a diagnostic and prognostic tool The utility of molecular genetic studies in the diagnosis, prognostic assessment and monitoring of lymphoid malignancies Radiologic, ultrasound and magnetic resonance imaging Radionuclide imaging Staging systems and staging investigations at presentation Special aspects of diagnosis in developing countries Imaging lymphomas in developing countries GENERAL PRINCIPLES OF MANAGEMENT Emergency management in lymphoid malignancies Systemic therapy of lymphoma Role of radiation therapy Response assessment and follow-up of the patient with malignant lymphoma Prognostic factors and risk adaptation Second-line therapy for lymphoid neoplasms High-dose therapy with stem cell rescue Management of lymphoid neoplasia during pregnancy Management of lymphoid malignancies in the infant Management of lymphoid neoplasms in the elderly Management of lymphomas at extranodal locations Special aspects of management of lymphomas in developing countries Late effects of cancer treatment and quality of life MANAGEMENT OF SPECIFIC DISEASES Lymphoblastic lymphoma and leukemia in children Acute lymphoblastic leukemia and lymphoma in adults Small B cell lymphomas and leukemias with hairy cell leukemia Mantle cell lymphoma Marginal zone lymphomas Follicular lymphoma Burkitt lymphoma/leukemia in children Burkitt and Burkitt like lymphoma/leukemia in adults Diffuse large B cell lymphoma in children Diffuse large B cell lymphomas in adults Hodgkin lymphoma in adults Hodgkin lymphoma in children Plasma cell neoplasms The management of natural killer cell malignancies Anaplastic large cell lymphoma in adults Anaplastic large cell lymphoma in children Mycosis fungoides and Sezary Syndrome Adult T-cell leukemia/lymphoma Other peripheral T cell lymphomas HIV-associated lymphoid neoplasms Lymphoid neoplasms in immunodeficiency, immunosuppression, and autoimmunity Uncommon histologic subtypes of non-Hodgkin lymphoma in children FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT Molecular profiling and lymphoma diagnosis New therapies for lymphoid neoplasms Monoclonal antibody therapy for lymphomas and leukemias Cellular therapies for lymphoma Vaccine therapies Lymphoma microenvironment Molecular pathway therapy for non-Hodgkin lymphomas Therapeutic strategies employing viral-associated targets

Product Details

  • ISBN13: 9780340809471
  • Format: Hardback
  • Number Of Pages: 1689
  • ID: 9780340809471
  • weight: 4581
  • ISBN10: 0340809477
  • edition: 3rd New edition

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