The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
The maternal-fetal interface - morphological variation in the interhaemal areas of chorioallantoic placentae; foeto-maternal anchorage in epitheliochorial and endotheliochorial placental types studied by histology and microvascular corrosion casts; simple and efficient stereological quantification of some placental structures; retinoids and mouse placentation; the role of cell adhesion molecules in placental development and barrier function; vertical transmission of infectious diseases - perinatal HIV-1 transmission in the United States and internationally; infection and immunity at the maternal-placental-fetal interface - focus on HIV-1; nonspecific immunity in the uterus and placenta; fine regulation of HLA class 1a gene expression in term human villous trophoblast cells; pregnancy and perforin - what could be the role of a "natural killer" in the decidua? maternalfoetal immune interactions - implications for intrauterine infections; interferon production at the human foeto-placental interface; coinfection as a factor in vertical viral transmission; in situ PCR discriminates between infected and uninfected human placental explants after in vitro exposure to HIV-1; HIV-1 infection of human placental villous tissue in vitro; the role of the placenta in the vertical transmission of HIV and other infectious agents; transfer of drugs - drug transfer across the term placenta; in vivo study of placental drug transfer during the first trimester of human pregnancy; liposome as a drug carrier system -prospects of safer prescribing during pregnancy; transfer of drugs across the placenta; trophoblast proliferation, differentiation and invasion - role of cyclic AMP-dependent protein kinases in human villous cytotrophoblast differentiation; the expression of ERV-3 mRNA in a choriocarcinoma model of trophoblastic differentiation; role of growth factors and other placental signals in extravillous trophoblast cell function; the endothelin/endothelin receptor system of human trophoblast in normal and pre-eclamptic pregnancies; regulation and endocrinology - the placental clock; maternal recognition of pregnancy - comparative aspects; hypoxia-mediated downregulation of human chorionic gonadotropin subunit mRNA expression in cytotrophoblastic JAr cells; stem villous arteries as regulatory of fetal placental blood flow; parturition.