Research into the neuropsychiatry of epilepsy has become a central focus of interest in the last five years. Comorbidity of epilepsy with behavioral problems is now recognized widely, and the neuroscientific basis for such comorbidity is an active area of investigation. With an expanded international team of authors, this fully revised new edition builds on the strengths of its predecessor, examining in detail the subtleties of behavioral changes in patients with seizure disorders and offering both a diagnostic and a management perspective. New chapters cover genetic disorders, the effects of epilepsy on social behavior as viewed through theory of mind, a discussion of the precuneus, the importance and nature of peri-ictal psychiatric symptoms, depression and the interictal dysphoric disorder, and the relationship between antiepileptic drugs and suicide. This new edition is a must for anyone involved in diagnosing or managing epilepsy.
Michael R. Trimble is Emeritus Professor at the Institute of Neurology, Queen Square, London, UK. Bettina Schmitz is Head of the Department of Neurology, the Stroke Unit and Epilepsy Center, Vivantes Humboldt-Klinikum, Berlin, Germany, and Professor of Neurology at the Charite University Hospital, Berlin.
1. Introduction Michael R. Trimble and Bettina Schmitz; 2. Neuropsychiatric disorders in epilepsy - epidemiology and classification Dale C. Hesdorffer and E. S. Krishnamoorthy; 3. Genetic disorders associated with intellectual disability Mike Kerr and Penny Blake; 4. Epilepsy and autistic spectrum disorders Thierry Deonna and Eliane Roulet-Perez; 5. Subtle cognitive and behavioral effects of epilepsy Frank M. C. Besag; 6. Dementia and epilepsy Bernd Pohlmann-Eden and Marie-Aline Eden; 7. Peri-ictal psychiatric phenomena Andres M. Kanner; 8. Postictal psychoses, established facts and new clinical questions Kousuke Kanemoto; 9. The interictal dysphoric disorder Marco Mula; 10. Behavioral and neuropsychological aspects of frontal and temporal lobe epilepsy Christoph Helmstaedter and Juri-Alexander Witt; 11. Emotional agnosis and theory of mind Sarah D. Broicher and Hennric Jokeit; 12. Nonepileptic seizures Tanvir U. Syed and W. Curt LaFrance, Jr; 13. The effects of antiepileptic drugs on behaviour Bettina Schmitz; 14. Antiepileptic drugs and suicide Michael R. Trimble; 15. Antiepileptic drugs and cognitive disorders Albert P. Aldenkamp; 16. Psychiatric illness and psychotropic medication use in epilepsy Jane V. Perr and Alan Ettinger; 17. Psychiatric effects of surgery for temporal lobe epilepsy Steffi Koch-Stoecker; 18. Brain mechanisms of impaired consciousness in epilepsy Andrea Eugenio Cavanna and Fizzah Ali; Index.