Dr. Maronde has performed a major service in bringing together a superb array of scholars and clinicians to discuss not only the basic principles in therapeutics and clinical pharmacology but also the application of those principles to a wide range of clinical problems. Inclusion of chapters on adverse drug reactions, drug overdose, nonmedical prescription drug use, physician prescribing patterns, and the pharmaceutical industry makes this a particularly valuable book for clinicians. It is increasingly important that clinicians be well grounded in the principles of pharmacodynamics and pharmacokinetics because more and more of our patients are aging and cannot be treated as young or middle-aged adults. Elderly patients are liable to either drug overdose or underdose if traditional dosage formulas are followed because of changes in drug metabolism, drug distribution within the body, drug excretion, or changes in receptor site sensitivity. Because the elderly often present with mUltiple chronic diseases and require a variety of medications, they are more prone to medication errors, drug-drug interactions, and adverse drug reactions. The inclusion of three excellent chapters relating to drug-drug interactions, adverse drug reactions, and drug overdose is most welcome and is a valuable addition to this outstanding text on therapeutics and clinical pharmacology. Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions.
1 Principles of Pharmacokinetics.- 2 Stochastic Control of Pharmacokinetic Systems.- 3 Clinical Applications of Pharmacokinetics and Control Theory: Planning, Monitoring, and Adjusting Dosage Regimens of Aminoglycosides, Lidocaine, Digitoxin, and Digoxin.- 4 Pharmacologic Interventions in Angina.- 5 Pharmacologic Interventions in Acute Myocardial Infarction.- 6 Afterload Reduction.- 7 Clinical Pharmacology and Therapy of Peptic Ulcer Disease.- 8 Hypokalemia, Potassium Supplements, and Potassium-Sparing Agents.- 9 The Use of Diuretics.- 10 Nonemergent Treatment of Hypertension.- 11 The Treatment of Malignant Hypertension.- 12 Sympathomimetic Amines in the Treatment of Shock.- 13 Treatment of Bacterial Infections of the Central Nervous System.- 14 Prophylactic Antibiotics.- 15 Antiinflammatory and Immunosuppressive Drugs in the Treatment of Rheumatoid Arthritis.- 16 Antiinflammatory and Immunosuppressive Drugs in the Treatment of Systemic Lupus Erythematosus.- 17 Acute Reversible Airflow Obstruction (Asthma).- 18 Chronic Airflow Obstruction.- 19 Drugs for Treating Anxiety and Depression.- 20 Harmful Drug-Drug Interactions.- 21 Adverse Drug Reactions.- 22 Diagnosis and Treatment of Drug Overdose.- 23 Nonmedical Prescription Drug Use.- 24 The Prescribing Practices of Physicians.- 25 The Pharmaceutical Industry: Development and Marketing of Prescription Drugs.
Number Of Pages:
Softcover reprint of the original 1st ed. 1986