Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors

By: Akhlaq A. Farooqui (editor), Tahira Farooqui (editor)Hardback

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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

About Author

Tahira Farooqui has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, biogenic amines mediated signaling, neural plasticity, as well as neuromoulatory roles of octopamine in the reinorcepathway involved in learning and memory, glycerophospholipid and sphingolipid metabolism and molecular signaling mechanisms in the brain. She is the author of 65 peer-reviewed research articles, one monographs and 8 edited books. She has coauthored a monograph in 2008 Metabolism and Function of Bioactive Ether Lipids in the Brain, 2008, by Springer, and have edited 8 Life Sciences books:1) Biogenic Amines: Pharmacological, Neurochemical, and Molecular Aspects in CNS, 2010, NOVA Science Publishers; 2) Phytochemicals and Human Health: Pharmacological and Molecular Aspects, 2011, NOVA Science Publishers; 3) Molecular Aspects of Neurodegeneration and Neuroprotection, 2011, Bentham Science Publishers; 4) Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Oxidative Stress on Cell Signaling, 2012, John Wiley & Sons, Inc; 5) Beneficial effects of propolis on human health and chronic diseases. Vol I, 2012, NOVA Science Publishers, Hauppage, New York; 6) Tahira Farooqui and Akhlaq A. Farooqui, Beneficial effects of propolis on human health and chronic diseases. Vol II, 2012, NOVA Science Publishers, Hauppage, New York; 7) Metabolic Syndrome and Neurological Disorders, 2013, John Wiley & Sons, Inc.; and 8) Diet and Exercise in Cognitive Function and Neurological Diseases, 2015, John Wiley & Sons, Inc. Akhlaq A. Farooqui is a leader in the field of signal transduction, brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, glutamate-induced neurotoxicity and modulation of signal transduction by phytochemicals. He has published more than 200 hundred papers, authored 11 monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); and Hot Topics in Neural Membrane Lipidology (2009); Beneficial Effects of Fish Oil in Human Brain (2009); Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases (2010); Lipid Mediators and their Metabolism in the Brain (2011); Phytochemicals, Signal Transduction, and Neurological Disorders (2012); Metabolic Syndrome: An Important Risk Factor for Stroke, Alzheimer Disease, Depression (2013); Inflammation and Oxidative Stress in Neurological Disorders (2014); High Calorie Diet and the Human Brain: Consequences of Long Term Consumption (2015); Therapeutic Potentials of Curcumin for Alzheimer Disease (2016). All monographs are published by Springer, New York. Akhlaq A. Farooqui has edited 10 books published by Wiley Blackwell Publishing Company, New York; Nova Science Publisher, New York; Bentham Science Publishers, Dubai, and Elsevier, San Diego, CA.


Section I. Introduction and Description of Trace Amines and Trace Amine-Associated Receptors 1. Trace Amines: An Overview 2. Methods of Trace Amines Analysis in Mammalian Brain 3. Synthesis and Neurochemistry of Trace Amines 4. The Origin and Evolution of the Trace Amine-Associated Receptor Family in Vertebrates 5. Differential Modulation of Adrenergic Receptor Signaling by Octopamine, Tyramine, Phenylethylamine, and 3-Iodothyronamine 6. Effects of Trace Amines on the Dopaminergic Mesencephalic System 7. Trace Amine-Associated Receptors in the Cellular Immune System 8. Trace Amines and Their Receptors in the Control of Cellular Homeostasis 9. Trace Amine-Associated Receptor 1 Modulation of Dopamine System 10. Trace Amines as Intrinsic Monoaminergic Modulators of Spinal Cord Functional Systems 11. Trace Amine-Associated Receptors: Ligands and Putative Role in the Central Nervous System 12. B-Phenylethylamine Requires the Dopamine Transporter to Release Dopamine in Caenorhabditis elegans Section II. Trace Amines and Olfaction 13. Trace Amines-Mediated Olfactory Learning and Memory in Mammals and Insects: A Brief Comparative Review 14. Octopaminergic and Tyraminergic Signaling in the Honeybee (Apis mellifera) Brain: Behavioral, Pharmacological, and Molecular Aspects 15. Octopamine and Tyramine Signaling in Locusts: Relevance to Olfactory Decision-Making Section III. Trace Amines and Neurological Disorders 16. Neurochemical Aspects of Neurological Disorders 17. Trace Amines and Their Relevance to Neurological Disorders: A Commentary 18. Trace Amines in Neuropsychiatric Disorders 19. B-Phenylethylamine-Class Trace Amines in Neuropsychiatric Disorders: A Brief Historical Perspective 20. Involvement of So-Called D-Neuron (Trace Amine Neuron) in the Pathogenesis of Schizophrenia: D-Cell Hypothesis 21. 3-Iodothyronamine, a New Chapter in Thyroid Story: Implications in Learning Processes 22. Trace Amine Receptors and Mood Disorders 23. Trace Amine Associated Receptor 1: Implications for Treating Stimulant Drug Addiction 24. Trace Amines and Their Potential Role in Primary Headaches Section IV. Perspective 25. Perspective and Directions for Future Research on Trace Amines and Neurological Disorders

Product Details

  • ISBN13: 9780128036037
  • Format: Hardback
  • Number Of Pages: 432
  • ID: 9780128036037
  • weight: 1500
  • ISBN10: 0128036036

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