The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants.
With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: Provides a comprehensive overview of the rapidly evolving field and developing formulation methods Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
MANMOHAN SINGH, M.Pharm., PhD, has worked in the area of vaccine adjuvants and delivery systems for seventeen years and has authored over eighty-five manuscripts and review articles. Dr. Singh is on the editorial board of five international journals and has contributed several book chapters. He is a Director of Vaccine Research within Novartis Vaccines.
Contributors. Preface. Chapter 1. Development of vaccine adjuvants - a historical perspective (Gary Ott and Gary Van Nest). Chapter 2. Antigen-Processing and Presentation (Subash Sad). Chapter 3. Mechanisms of Adjuvant Action (Nils Lycke). Chapter 4. Aluminum-containing Adjuvants: Properties, Formulation and Use (Stanley L. Hem and Harm HogenEsch). Chapter 5. MF59: A Safe and Potent Oil in Water Emulsion Adjuvant (D.T. O'Hagan). Chapter 6. TLR4 agonists as vaccine adjuvants (David A. Johnson and Jory R. Baldridge). Chapter 7. Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants (Dennis M. Klinman, Debbie Currie and Hidekazu Shirota). Chapter 8. Small Molecule Immunopotentiators as Vaccine Adjuvants (Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer). Chapter 9. New ISCOMs Meet Unsettled Vaccine Demands (Bror Morein, Kefei Hu, Karin Lovgren, and Erik Dhondt). Chapter 10. Surface Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems (Manmohan Singh, James Chesko, Jina Kazzaz and Derek T. O'Hagan). Chapter 11. Liposomal Cytokines and Liposomes Targeted to Costimulatory Molecules as Adjuvants for HIV Subunit Vaccines (Bulent Ozpolat and Lawrence B. Lachman). Chapter 12. Archaeosomes Vaccine Adjuvants for Cross-priming CD8+ T Cell Immunity (Lakshmi Krishnan and G. Dennis Sprott). Chapter 13 Mucosal Adjuvants and Delivery Systems (Michael Vajdy). Chapter 14. Cytokines as Vaccine Adjuvants (Nejat Egilmez). Chapter 15. Polyphosphazenes as vaccine adjuvants (Alexander K. Andrianov). Chapter 16. Vaccine Delivery by Transdermal Electroporation (Amit Misra). Chapter 17. Nonclinical Safety Assessment of Vaccines, and the Evaluation of Novel Adjuvants and Delivery Systems (Jose A. Lebron, Jayanthi J. Wolf, Catherine V. Kaplanski, and Brian J. Ledwith). Chapter 18. Safety Evaluation of Vaccine Adjuvants (Erik B. Lindblad).