Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

By: Manmohan Singh (editor)Hardback

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The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: Provides a comprehensive overview of the rapidly evolving field and developing formulation methods Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

About Author

MANMOHAN SINGH, M.Pharm., PhD, has worked in the area of vaccine adjuvants and delivery systems for seventeen years and has authored over eighty-five manuscripts and review articles. Dr. Singh is on the editorial board of five international journals and has contributed several book chapters. He is a Director of Vaccine Research within Novartis Vaccines.


Contributors vii Preface ix 1 Development of Vaccine Adjuvants: A Historical Perspective 1Gary Ott and Gary Van Nest 2 Antigen Processing and Presentation 33Subash Sad 3 Mechanisms of Adjuvant Action 53Nils Lycke 4 Aluminum-Containing Adjuvants: Properties, Formulation, and Use 81Stanley L. Hem and Harm HogenEsch 5 MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant 115Derek T. O Hagan and Manmohan Singh 6 TLR4 Agonists as Vaccine Adjuvants 131David A. Johnson and Jory R. Baldridge 7 Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants 157Dennis M. Klinman, Debbie Currie, and Hidekazu Shirota 8 Small Molecule Immunopotentiators as Vaccine Adjuvants 175Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer 9 New ISCOMs Meet Unsettled Vaccine Demands 191Bror Morein, Kefei Hu, Karin Loevgren, and Erik D Hondt 10 Surface-Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems 223Manmohan Singh, James Chesko, Jina Kazzaz, Mildred Ugozolli, Padma Malyala, and Derek T. O Hagan 11 Liposomal Cytokines and Liposomes Targeted to Co-Stimulatory Molecules as Adjuvants for HIVSubunit Vaccines 249Bulent Ozpolat and Lawrence B. Lachman 12 Archaeosome Vaccine Adjuvants for Cross-Priming CD8+T-Cell Immunity 263Lakshmi Krishnan and G. Dennis Sprott 13 Mucosal Adjuvants and Delivery Systems 295Michael Vajdy 14 Cytokines as Vaccine Adjuvants 327Nejat K. Egilmez 15 Polyphosphazenes as Vaccine Adjuvants 355Alexander K. Andrianov 16 Vaccine Delivery by Transdermal Electroporation 379Amit Misra 17 Nonclinical Safety Assessment of Vaccines and the Evaluation of Novel Adjuvants and Delivery Systems 403Jose A. Lebron, Jayanthi J. Wolf, Catherine V. Kaplanski, and Brian J. Ledwith 18 Safety Evaluation of Vaccine Adjuvants 421Erik B. Lindblad Index 445

Product Details

  • ISBN13: 9780471739074
  • Format: Hardback
  • Number Of Pages: 470
  • ID: 9780471739074
  • weight: 796
  • ISBN10: 0471739073

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