Generations of new vaccines such as DNA-based vaccines, multipeptide, lipopeptide, molecular, cellular and replicon-based vaccines are currently being developed to help combat viral, bacterial, and parasitic infections, and non-infectious diseases including cancer, autoimmune diseases, allergies, neurodegenerative and metabolic diseases. In this book internationally acclaimed authors review current strategies and approaches in vaccine development. Topics covered include the immunological basis for rational design of new vaccines, targeting the innate immune system, mucosal immunity, vaccine safety, and vaccine vector technology. Several chapters are devoted to the development of vaccines to combat specific diseases such as tuberculosis, nosocomal infections, rotaviruses, human papillomavirus, cancer, and allergies.
1. Driving Forces in the Development of Innovative Vaccines. 2. Immunological Basis for the Rational Design of New Vaccines. 3. Targeting Innate Immunity With Adjuvants: Can Accurate Danger Signals Drive More Protective Immune Responses? 4. Mucosal Immunity and Vaccine Design. 5. Immunization Using the Skin: New Approaches. 6. Cellular Vaccines: Current Status. 7. Veterinary Applications of the Canarypox Vaccine Vector Technology: Recent Developments for Vaccines in Domestic Mammalian Species. 8. Immunological Aspects of Vaccine Safety: Where Do We Go? 9. Vaccines Against Nosocomial Infections. 10. TB Vaccine Development: Opportunity and Imperative. 11. Development of a Vaccine Against Rotaviruses: Current Status. 12. Development of a Vaccine Against Human Papillomavirus (HPV). 13. Development of Cancer Vaccines: Current Status. 14. Antigen-specific Immunotherapy for Allergies.