Vitamin D: Volume 1: Biochemistry, Physiology and Diagnostics (4th edition)

Vitamin D: Volume 1: Biochemistry, Physiology and Diagnostics (4th edition)

By: Martin Hewison (editor), J. Wesley Pike (editor), David Feldman (editor), Roger Bouillon (editor), David Goltzman (editor), Edward Giovannucci (editor)Hardback

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Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

About Author

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition. Dr. Pike's laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action. Roger Bouillon, MD, PhD, FRCP, biography Roger Bouillon is professor (emeritus since 2010) in endocrinology (internal medicine) at the University and University Hospital of the Catholic University of Leuven (K.U.Leuven) in Belgium. He is a member of the Royal Academy of Medicine (Belgium) and a Fellow of the Royal College of Physicians (London). He was a founding member and later President of the European Board of Endocrinology (UEMS 1988-2002). He was a member of several European Science Foundation Committees (Board member of the European Medical Research Council) and of the European Space Agency Life Science working group till 2012. He is past-president of the International Bone and Mineral Society (2011-13 ) and is co-organizer of the vitamin D workshop. He was vice president for research of the University of Leuven from 1995-2005. He is coauthor of more than 500 peer reviewed articles that generated about 26,000 ISI citations and a H index of 82. The topics of his research deal with (1) several aspects of diabetes an endocrinology in general but his main research focus deals with (2) hormonal aspects of bone and calcium homeostasis and this spans the spectrum of basic, translational and clinical research. (3) Vitamin D is a major research focus throughout his scientific career. Papers: Edward Giovannucci's research focuses on how nutritional, genetic, environmental and lifestyle factors relate to various malignancies, especially those of the prostate and large bowel. Much of his work is centered on large ongoing cohort studies, including the Nurses Health Study, the Health Professionals Follow-Up Study and the Physicians Health Study. A specific area of interest is the etiologic mechanisms underlying the relation between modifiable factors and cancer risk. His work has included the study of how nutrition and other lifestyle factors impact on cancer risk and progression by influencing levels of insulin, insulin-like growth factors, vitamin D metabolites, and steroid hormones. Another area of interest is how nutrients may interact with genetic susceptibilities in determining an individual's risk. David Goltzman is Professor in the Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician in the Endocrine Division of the Department of Medicine of the McGill University Health Centre. His research has focused on the hormonal regulation of mineral and skeletal homeostasis, and he has made many important contributions to our knowledge of parathyroid hormone (PTH), PTH related peptide and vitamin D, which have had major impact on our understanding of a variety of metabolic bone diseases. He is also principal investigator of the Canadian Multicentre Osteoporosis Study (CaMos) which examines the demographics, development, risk factors and outcomes of osteoporosis. Dr. Goltzman has received various honours and awards, including the Aurbach Award of the US Endocrine Society, the Raisz Award of the American Society for Bone and Mineral Research (ASBMR), fellowship in the Royal Society of Canada and in the Canadian Academy of Health Sciences, the Order of Canada, an honorary professorship from Nanjing University and the degree of Doctor Honoris Causa from the University of Athens. He is a past President of the ASBMR, the Canadian Society of Clinical Investigation and the Canadian Society of Endocrinology and Metabolism. Prof. Hewison's work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.


Volume 1: Biochemistry, Physiology and Diagnostics In Memoriam: Robert P. Heaney, MD (1928-2016) In Memoriam: Milan Uskokovic, PhD (1924-2015) Section I. History, Chemistry Metabolism, Circulation & Regulation 1. Historical Overview of Vitamin D 2. Evolutionary Biology: Mysteries of Vitamin D in Fish 3. Evolution of Human Skin Color and Vitamin D 4. Photobiology of Vitamin D 5. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases) 6. CYP24A1: Structure, Function, and Physiological Role 7. The Vitamin D Binding Protein DBP 8. Regulation of renal and extra-renal 1a-hydroxylase Section II. Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells 10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor 11. Structural basis for ligand activity in VDR 12. Ligand Independent Actions of Vitamin D Receptor 13. Vitamin D and Chromatin 14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR 15. Vitamin D and microRNAs 16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions Section III. Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function 18. Osteoclastogenesis and Vitamin D 19. Vitamin D Activities in Osteocytes 20. Regulation of Intestinal Calcium and Phosphate Absorption 21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 22. Calcium homeostasis and eggshell biomineralization in female chicken 23. Mineralization in Mammals 24. Cartilage 25. Vitamin D and Bone: An Integrated Approach Section IV. Extra-Skeletal Targets 26. Vitamin D and the Kidney 27. Vitamin D and the Parathyroids 28. The Calcium-sensing Receptor and Vitamin D 29. Vitamin D in Dentoalveolar and Oral Health 30. The Role of Vitamin D and its Receptor in Hair Follicle Biology 31. Vitamin D, Calcium and the Epidermis 32. Vitamin D and the Cardiovascular System 33. Vitamin D Brain Development and Function 34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms 35. Vitamin D and Skeletal Muscle 36. Understanding Vitamin D from mouse knockout models Section V. Human Physiology 37. Pharmacology and pharmacokinetics 38. Vitamin D Role in the Calcium and Phosphorus Economies 39. Fetus, Neonate and Infant 40. Consequences of perinatal vitamin D deficiency on later bone health 41. Adolescence and Acquisition of Peak Bone Mass 42. Pregnancy, Lactation, and Post-Weaning Recovery 43. Role in Reproductive Biology and Reproductive Dysfunction in Women 44. Vitamin D, reproductive biology, and dysfunction in men 45. Vitamin D and the Renin-Angiotensin System 46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin 47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and L. Darryl Quarles Section VI. Diagnosis and Management 48. Approach to the Patient with Metabolic Bone Disease 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology 50. Mass Spectrometry Assays of Vitamin D Metabolites 51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation 53. Bone Histomorphometry 54. Radiology of Rickets and Osteomalcia 55. High-resolution Imaging Techniques for Bone Quality Assessment 56. The Role of Vitamin D in Orthopedic Surgery 57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position 57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position

Product Details

  • ISBN13: 9780128099650
  • Format: Hardback
  • Number Of Pages: 1180
  • ID: 9780128099650
  • weight: 3500
  • ISBN10: 0128099658
  • edition: 4th edition

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