The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases
A Doody's Core Title for 2017!
Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.
The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.
Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.
Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NY Senior Vice President, Health Sciences Dean, School of Medicine Stony Brook University Stony Brook, NY Professor of Medicine, Pathology, and Genetics Hematology Division University of Utah Salt Lake City, Utah Department of Pathophysiology First Faculty of Medicine Charles University in Prague Czech Republic Chairman, Department of MedicineAcademic Medical CenterUniversity of AmsterdamAmsterdam, The Netherlands
1 Initial approach to the patient: History and physical examination 2 Examination of blood cells 3 Examination of the marrow 4 Consultative Hematology 5 Structure of the marrow and hematopoietic microenvironment 6 The organization and structure of lymphoid tissues 7 Hematology of the fetus and newborn 8 Hematology during pregnancy 9 Hematology in older persons 10 Genetic principles 11 Genomics 12 Epigenetics 13 Cytogenetic and Genetic Abnormalities 14 Metabolism of Hematological Neoplastic Cells 15 Apoptosis and Autophagy 16 Cell cycle regulation and hematological disorders 17 Signal transduction pathways 18 Hematopoietic stem cells, progenitors, and cytokines 19 The inflammatory response 20 Innate immunity 21 Adaptive immunity 22 Pharmacology and toxicity of antineoplastic drugs 23 Hematopoietic stem cell transplantation 24 Treatment of infections in the immunocompromised host 25 Antithrombotic therapy 26 Immune cell therapy 27 Vaccine therapy 28 Therapeutic apheresis: indications, efficacy, and complications 29 Gene transfer for therapy 30 Regenerative Medicine: Multipotential cell therapy for tissue replacement 31 Structure and Composition of the Erythrocyte Absorb former 30 Composition of Erythrocyte. 32 Erythropoiesis 33 Erythrocytes turnover 34 Clinical manifestations and classification of erythrocyte disorders 35 Aplastic anemia 36 Pure red cell aplasia 37 Anemia of chronic disease 38 Erythropoietic effects of endocrine disorders 39 The congenital dyserythropoietic anemias 40 Paroxysmal nocturnal hemoglobinuria 41 Folate, cobalamin and megaloblastic anemias 42 Iron Metabolism 43 Iron deficiency and overload 44 Anemia resulting from other nutritional deficiencies