This book brings together specialist authors from a variety of medical disciplines to give comprehensive coverage of the whole spectrum of women's vascular health. Covering coronary artery disease and its precursors, venous disease, thrombophilic defects, hormonal therapy and haemorrhagic problems, the content is divided into three sections.
Section one reviews generic issues including the pathophysiology of arteriosclerosis, metabolic factors in vascular disease, the epidemiology and management of CHD in women. The management of cardiac syndrome X and the problem of diabetes are also discussed here. The second section looks at women's vascular health as it applies to fertility issues and during pregnancy such as polycystic ovarian disease, menstrual dysfunction, the menopause, venous thromboembolism and haemorrhagic problems. In the concluding third section, hormonal therapy in women and in particular the oral contraceptive pill and hormone replacement therapies are covered.
The reader will be given a clear overview of the potential mechanisms whereby such therapy can act as a risk factor for arterial and venous disease, and will receive clear guidance regarding prescribing.
Ian A. Greer, Regius Professor of Obstetrics & Gynaecology, University of Glasgow, UK Jeffrey Ginsberg, Professor of Medicine, McMaster University, Hamilton, Ontario, Canada Charles D. Forbes, Professor of Medicine, Ninewells Hospital and Medical School, University of Dundee, UK
SECTION 1: OVERVIEW 1. Epidemiology of vascular disease in women 2. Pathophysiology of arterioscleriosis 3. Metabolic risk factors for vascular disease in women 4. Genetic factors in vascular disease 5. Diabetes mellitus in women 6. Haemostatic factors in vascular disease 7. Congenital Thrombophilia and Venous Disease 8. Acquired thrombophilia 9. Congenital and acquired haemorrhagic problems 10. The Vasculitides 11. Anticoagulants / anticoagulants in pregnancy 12. Antiplatelet agents 13. Prophylaxis of venous and arterial thromboembolism in medical and surgical patients 14. Management of coronary artery disease including syndrome X in women 15. Peripheral vascular disease in women 16. Cerebrovascular disease 17. Cancer and thrombosis in women 18. Management of DVT and PTE including longterm sequelae SECTION 2: REPRODUCTIVE PROBLEMS 19. Irregular menstrual bleeding 20. Polycystic ovarian syndrome and vascular disease 21. The effect of pregnancy on the haemostatic and metabolic systems 22. Venous thrombosis in pregnancy 23. Venous thrombosis and ovarian stimulation 24. Thrombophilia and pregnancy complications 25. Heart disease in pregnancy 26. Hypertension, pre-eclampsia and intrauterine growth restriction 27. Thrombocytopenia in Pregnancy 28. Gestational diabetes 29. Maternal & fetal programming SECTION 3: HORMONAL THERAPY IN WOMEN 30. Epidemiology of the combined oral contraceptive pill and thrombosis 31. The oral contraceptive pill, mechanisms of vascular risk and practical prescribing strategies for women with thrombotic problems 32. Epidemiology of HRT and vascular disease 33. Hormone replacement therapy and mechanism of vascular risk 34. Practical strategies for HRT prescribing