Workbook for Organic Synthesis: Strategy and Control

Workbook for Organic Synthesis: Strategy and Control

By: Paul Wyatt (author), Stuart Warren (author)Paperback

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Description

This workbook accompanies Organic Synthesis: Strategy andControl, the bestselling advanced organic textbook Provides a complete course for advanced organic students andincludes a graded set of problems, solutions and discussions toillustrate and develop the themes of each of the chapters in thetextbook

About Author

Dr Paul Wyatt, School of Chemistry, University of Bristol, Bristol Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. Dr Stuart Warren, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley) and Organic Synthesis (OUP)

Contents

Preface vii A: Introduction: Selectivity 1 1. Planning Organic Syntheses: Tactics, Strategy and Control 3 2. Chemoselectivity 7 3. Regioselectivity: Controlled Aldol Reactions 19 4. Stereoselectivity: Stereoselective Aldol Reactions 35 5. Alternative Strategies for Enone Synthesis 47 6. Choosing a Strategy: The Synthesis of Cyclopentenones 57 B: Making Carbon?Carbon Bonds 69 7. The Ortho Strategy for Aromatic Compounds 71 8. ?-Complexes of Metals 91 9. Controlling the Michael Reaction 103 10. Specific Enol Equivalents 115 11. Extended Enolates 123 12. Allyl Anions 135 13. Homoenolates 147 14. Acyl Anion Equivalents 155 C: Carbon?Carbon Double Bonds 169 15. Synthesis of Double Bonds of Defined Stereochemistry 171 16. Vinyl Anions 191 17. Electrophilic Attack on Alkenes 203 18. Vinyl Cations 221 19. Allyl Alcohols: Allyl Cation Equivalents (and More) 241 D: Stereochemistry 257 20. Control of Stereochemistry?Introduction 259 21. Diastereoselectivity 269 22. Resolution 283 23. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials 295 24. Asymmetric Induction I: Reagent-Based Strategy 309 25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C?O and C?N Bonds 321 26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C?H and C?C Bonds 335 27. Asymmetric Induction IV: Substrate-Based Strategy 351 28. Kinetic Resolution 365 29. Enzymes: Biological Methods in Asymmetric Synthesis 377 30. New Chiral Centres from Old: Enantiomerically Pure Compounds and Sophisticated Syntheses 391 31. Strategy of Asymmetric Synthesis 405 E: Functional Group Strategy 417 32. Functionalisation of Pyridine 419 33. Oxidation of Aromatic Rings and of Enol(ate)s 433 34. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements 447 35. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms 459 36. Tandem Organic Reactions 473 Index 483

Product Details

  • ISBN13: 9780471929642
  • Format: Paperback
  • Number Of Pages: 502
  • ID: 9780471929642
  • weight: 954
  • ISBN10: 0471929646

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