The completion of the human genome and technological advances developed by the Human Genome Project have dramatically changed our understanding of the mechanisms underlying the development and differentiation of male germ cells, and our ability to investigate such mechanisms. This book is a timely document of advances made in the field of male gonad and germ cell research in the postgenomic era.The coverage includes the role of Y chromosome genes in male reproduction, gene expression in spermatogonial stem cells and male germ cells, and the regulation of germ cell genes in reproduction and in germ cell tumors.
Introduction (O M Rennert); The Roles of Mouse Y Chromosome Genes in Spermatogenesis (P S Burgoyne & M J Mitchell); Male Meiotic Sex Chromosome Inactivation and Meiotic Silencing (J M A Turner & P S Burgoyne); Insights into SRY Action from Sex Reversal Mutations (M I Stahle et al.); The TSPY Gene Family (Y-F C Lau et al.); Structure and Function of AZFa Locus in Human Spermatogenesis (P H Vogt et al.); RBMY and DAZ in Spermatogenesis (P Yen); Neurotrophic Factors in the Development of the Postnatal Male Germ Line (M-C Hofmann & L Braydich-Stolle); Dickkopf-Like 1 -- A Protein Unique to Mammals That is Associated Both with Formation of Trophoblast Stem Cells and with Spermatogenesis (M J Kohn et al.); Antisense Transcription in Developing Male Germ Cells (W-Y Chan et al.); The Spermatogonial Stem Cell Model (M Dym & Z He); Transplantation of Germ Cells and Testis Tissue (I Dobrinski); Orthodox and Unorthodox Ways to Initiate Fertilization and Development in Mammals (R Yanagimachi); Pathogenesis of Testicular Germ Cell Tumors (L H J Looijenga); Origin of Testicular Germ Cell Neoplasia: The Role of Sex Chromosomes (E Rajpert-De Meyts et al.).