Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout.
Expert, international authorship and comprehensive, easy-to-access information makes this edition the gold standard in the field of hepatology.
Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, videos, and references from the book on a variety of devices.
Includes new information on the rapid changes in treatment paradigms for acute liver failure, the latest treatments for primary biliary cholangitis, full coverage of the gut microbiome and its role in liver disease, the newest developments in drug-induced liver injury, and changes in hepatitis C virus treatment and hot-button concerns about access to care.
New summary boxes at the end of each chapter and a newly streamlined table of contents make it easier to find and understand the information you're looking for.
Hundreds of brand-new illustrations clearly present key aspects of liver disease.
Section I. Basics 1. Anatomy and Cellular Functions of the Liver 2. Bile Acids and Bile Flow: New Functions of Old Molecules 3. Intestinal Microbiome and the Liver 4. Liver as an Immune Organ 5. Liver's Response to Injury: Inflammation and Fibrosis 6. Stem Cells and Hepatocyte Transplantation Section II. Management and Assessment of Liver Disease 7. Approach to Jaundice and Abnormal Liver Function Tests 8. Noninvasive Assessment of Disease Progression 9. Molecular and Genetics-Based Diagnostics 10. Imaging in Assessment of Liver Disease and Lesions 11. Evaluation of the Hepatic Mass 12. Assessment of Liver Histology 13. Critical Care Management of Patients with Liver Disease Section III. Clinical Consequences of Chronic Liver Disease 14. Neurologic Consequences of Liver Disease 15. Ascites and Hyponatremia 16. Portal Hypertension Related to Bleeding 17. Renal Failure in Cirrhosis 18. Cardiopulmonary Complications of Cirrhosis 19. The Hemostatic and Hematopoietic System in Liver Disease 20. Acute Liver Failure 21. Acute-on-Chronic Liver Failure Section IV. Specific Diseases 22. Epidemiology and Pathogenesis of Alcoholic Liver Disease 23. Natural History and Cofactors of Alcoholic Liver Disease 24. Prevention and Management of Alcoholic Liver Disease 25. Pathogenesis of Nonalcoholic Fatty Liver Disease 26. Epidemiology, Natural History, and Diagnosis of Nonalcoholic Fatty Liver Disease 27. Management of NAFL-NASH and Metabolic Syndrome 28. Virology and Pathogenesis of Hepatitis C 29. Epidemiology, Natural History, and Diagnosis of Hepatitis C 30. Treatment of Hepatitis C 31. Virology and Pathogenesis of Hepatitis B 32. Epidemiology, Natural History, and Diagnosis of Hepatitis B 33. Treatment of Hepatitis B 34. Hepatitis D 35. Hepatitis A 36. Hepatitis E Section V. Liver and Other Infections 37. HIV and the Liver 38. Liver Disease Associated with Systemic Viral Infection 39. Parasitic Liver Disease 40. Bacterial and Miscellaneous Infections of the Liver Section VI. Immune Diseases of the Liver 41. Autoimmune Hepatitis and Overlap Syndrome 42. Primary Biliary Cirrhosis 43. Primary and Secondary Sclerosing Cholangitis Section VII. Vascular Diseases of the Liver 44. Budd-Chiari and Sinusoidal Obstruction Syndrome 45. Portal and Splenic Vein Thrombosis Section VIII. Tumors of the Liver 46. Hepatocellular Carcinoma 47. Cholangiocarcinoma 48. Other Malignant Hepatic Tumors 49. Benign Liver Tumors Section IX. Liver Transplantation 50. Pretransplant Evaluation and Care 51. Transplantation of the Liver 52. Post Liver Transplant Management 53. Recurrent Primary Disease after Transplantation Section X. Liver Affected by Other Conditions or Diseases 54. Liver and Pregnancy 55. Nutrition and the Liver 56. Drug-Induced Liver Injury 57. Preoperative and Postoperative Hepatic Dysfunction Section XI. Inherited and Pediatric Liver Diseases 58. Bilirubin Metabolism and Its Disorders 59. Wilson Disease 60. Hemochromatosis 61. Alpha-1 Antitrypsin Deficiency 62. Approach to and Evaluation of Metabolic Liver Diseases 63. Pediatric Cholestatic Syndromes 64. Fibrocystic Diseases of the Liver 65. Viral Hepatitis in Children